CASE REPORT

Pathol. Oncol. Res.

Volume 31 - 2025 | doi: 10.3389/pore.2025.1612095

This article is part of the Special IssueCytometry in OncologyView all 3 articles

Case report: Flow cytometric differential diagnosis of a peripheral T-cell lymphoma, NOS with complete loss of CD45 and dim expression of CD3

Gábor SzalókiGábor Szalóki1Ágota SzepesiÁgota Szepesi1Ilona TárkányiIlona Tárkányi2Ágnes MárkÁgnes Márk1Csilla Tolnai-KristonCsilla Tolnai-Kriston1Anna HunyadiAnna Hunyadi1Réka MózesRéka Mózes1Gábor BarnaGábor Barna1*
  • 1Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
  • 2Department of Internal Medicine and Haematology, Faculty of Medicine, Semmelweis University, Budapest, Hungary

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Peripheral T-cell lymphomas (PTCLs) are a group of non-Hodgkin lymphomas originating from mature T-lymphocytes. Despite encompassing several well-defined entities, about 25% of the PTCLs do not fulfill the requirements of any of the subcategories. These diseases are classified as PTCL, not otherwise specified (PTCL, NOS), and often associated with poor prognosis. Hereby we present a case of a female patient, diagnosed with PTCL, NOS from her skin biopsy specimen. Besides histology and immunohistochemistry, flow cytometry was used for phenotyping and staging (peripheral blood, bone marrow). Pathologic T-cells were found in all the investigated tissues, with a very unusual CD45 negative and surface CD3 dim immunophenotype.

Keywords: Flow Cytometry, immunophenotype, peripheral T-cell lymphoma, differential diagnosis, PTCL, NOS

Received: 29 Jan 2025; Accepted: 06 May 2025.

Copyright: © 2025 Szalóki, Szepesi, Tárkányi, Márk, Tolnai-Kriston, Hunyadi, Mózes and Barna. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Gábor Barna, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

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