@ARTICLE{10.3389/pore.2022.1610638, AUTHOR={Ma, Yu-Ting and Li, Yan and Yan, Li and Hua, Fang and Wang, Dong-Guan and Xu, Guo-Ying and Yang, Hong-Lan and Xue, Ying-Jie and Qin, Ye-Jun and Sha, Dan and Ning, Hao and Zhao, Miao-Qing and Yao, Zhi-Gang}, TITLE={Case Report: Potential Predictive Value of MMR/MSI Status and PD-1 Expression in Immunotherapy for Urothelial Carcinoma}, JOURNAL={Pathology and Oncology Research}, VOLUME={28}, YEAR={2022}, URL={https://www.por-journal.com/articles/10.3389/pore.2022.1610638}, DOI={10.3389/pore.2022.1610638}, ISSN={1532-2807}, ABSTRACT={Immune checkpoint inhibitors (ICIs) have shown encouraging outcomes against Lynch syndrome (LS)-associated colorectal cancer (CRC) and endometrial cancer with mismatch repair deficient/microsatellite instability–high (dMMR/MSI-H). However, there is as yet no clarity on the safety and efficacy of immunotherapy combined with chemotherapy in LS-associated urothelial carcinoma (UC). Here, we report a patient with recurrent and metastatic LS-associated UC who achieved sustained response to programmed death protein 1 (PD-1) inhibitor combined with chemotherapy over 31 months, during which the side effects of immunotherapy could be controlled and managed. Our findings indicate that the dMMR/MSI status and PD-1 expression in UC may have potential predictive value for the response to PD-1-targeted immunotherapy. Our case supports the inclusion of such combination and/or monotherapy for UC in clinical studies and using dMMR/MSI status and PD-1 expression as potential predictive biomarkers for assessment of the therapeutic response.} }