The landscape of oncology is being transformed by targeted therapies, which rely heavily on the precision of molecular diagnostics. Modern pathology has evolved beyond morphological assessment to include complex genomic profiling, ensuring that treatments are tailored to the unique molecular signature of each tumor. Furthermore, the integration of AI-based algorithms is playing a critical role in this shift; by analyzing vast datasets of clinical and biological information, these technologies enable more accurate predictions of therapeutic responses and accelerate the discovery of novel biomarkers.

The rapid evolution of oncological precision medicine necessitates a profound integration of diagnostic pathology and computational informatics. The primary goal of this special issue is to provide a comprehensive platform for multidisciplinary research that elucidates how molecular diagnostics translate into tangible targeted therapies.
As we move beyond traditional morphology, the role of the pathologist has evolved into that of a data integrator. This issue aims to capture this transition by focusing on:

Integration of Multi-Omics Data: Exploring how NGS, proteomics, and transcriptomics are integrated into routine pathology workflows to identify actionable mutations and biomarkers.

Computational Pathology and AI: Demonstrating the use of informatics and artificial intelligence in analyzing complex histological patterns and genomic signatures to predict treatment efficacy.

Translational Synergy: Bridging the gap between the laboratory and the clinic by showcasing how molecularly-driven pathology reports directly influence decision-making in targeted therapy.

Authors are welcome to submit articles presenting original studies or literature review work. Please consult the journal's information regarding Author Guidelines, Article Types, and Publishing Fees, or direct any questions to the Editorial Office: por@por-journal.com.

Even though abstract submission is not mandatory, we encourage all interested researchers to submit a “manuscript summary” before submitting their article. Manuscript summaries do not have to coincide with the final abstract of the article.

Authors

Pathology and Oncology Research