@ARTICLE{10.3389/pore.2022.1610171, AUTHOR={Kertész, Gabriella and Kállay, Krisztián and Kassa, Csaba and Zombori, Marianna and Bodó, Imre and Kiss, Csongor and Szegedi, István and Kriván, Gergely}, TITLE={Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia}, JOURNAL={Pathology and Oncology Research}, VOLUME={28}, YEAR={2022}, URL={https://www.por-journal.com/articles/10.3389/pore.2022.1610171}, DOI={10.3389/pore.2022.1610171}, ISSN={1532-2807}, ABSTRACT={The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment, the preparation of the donor with severe hemophilia A required a special management with perioperative factor VIII substitution. Donation was successful without complications, and 18 months after transplantation, the patient and his donor are well without any long-term sequelae. To our knowledge, this is the first reported succesfull transplantation with hemophilic child serving as a bone marrow donor. The procedure did not mean a significant risk to donor health, so donors with hemophilia should not be excluded from donation.} }