%A Yang,AI %A Li,Min %A Fang,Mingzhi %D 2021 %J Pathology and Oncology Research %C %F %G English %K KRAS mutation,Targeted drugs,oncogene,inhibitor,oncology %Q %R 10.3389/pore.2021.631095 %W %L %M %P %7 %8 2021-April-23 %9 Review %+ Dr Min Li,Nanjing Traditional Chinese Medicine Hospital,Nanjing,China,doctorlimin@qq.com %# %! direct KRAS mutation inhibitors %* %< %T The Research Progress of Direct KRAS G12C Mutation Inhibitors %U https://www.por-journal.com/articles/10.3389/pore.2021.631095 %V 27 %0 JOURNAL ARTICLE %@ 1532-2807 %X Abstract: KRAS mutations have long been considered undruggable. However, a series of direct KRAS mutation inhibitors have been developed since the switch II pocket was discovered recently. This review will summarize progress in the development of direct KRAS G12C mutation inhibitors, current relevant drugs under study and challenges that need to be considered in future research.