AUTHOR=Han Zesen , Yang Fujun , Wang Fang , Zheng Huayu , Chen Xiujian , Meng Hongyu , Li Fenglei 

TITLE=Advances in combined neuroendocrine carcinoma of lung cancer

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 30 - 2024

YEAR=2024

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2024.1611693

DOI=10.3389/pore.2024.1611693

ISSN=1532-2807

ABSTRACT=Globally, the incidence and mortality rates of lung cancer are on the rise, posing a significant public health challenge and imposing immense burdens on affected families. Lung cancer encompasses distinct subtypes, namely non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). During clinical investigations, researchers have observed that neuroendocrine tumors can be classified into four types: typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma based on their unique features. However, there exist combined forms of neuroendocrine cancers. This study focuses specifically on combined pulmonary carcinoma with a neuroendocrine component. In this comprehensive review article, the authors provide an overview of combined lung cancers and present two pathological images to visually depict these distinctive subtypes.