AUTHOR=Tornyi Ilona , Árkosy Peter , Horváth Ildikó , Furka Andrea 

TITLE=A new perspective on the proper timing of radiotherapy during CDK4/6 inhibitor therapy in patients with “bone-only” metastatic breast cancer

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 29 - 2023

YEAR=2023

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2023.1611369

DOI=10.3389/pore.2023.1611369

ISSN=1532-2807

ABSTRACT=The vast majority of hormone positive and HER2 negative advanced breast cancers can be controlled well by endocrine therapy plus the breakthrough successfully implemented CDK4/6 inhibitors in the metastatic first-line setting. Approximately 50-60% of these patients have "bone-only" metastatic disease. In oligometastatic cases or if a certain number of uncontrolled lesions develop during above mentioned therapy, ablative radiotherapy can be delivered or in symptomatic cases urgent irradiation is needed with palliative intent. To reach the most effective result parallel with good quality of life, providential timing of radiotherapy has to be set precisely taking into account which cell cycle is involved during different treatment modalities therefore optimization of schedule ensures longer and safer post progression overall survival. The key question is whether the two treatment modalities are safe concurrently or should be administered separately, if so, what is the optimal sequence and why. This manuscript is meant to answer this very important question considering the quality of life. Available publications are focused on safety and toxicity profile and tangentially minimally detailed the efficacy.