AUTHOR=Zheng Ying , Li Zhe , Wang Yao , Chen Wanjiao , Lin Yifan , Guo Junming , Ye Guoliang TITLE=CircRNA: A new class of targets for gastric cancer drug resistance therapy JOURNAL=Pathology and Oncology Research VOLUME=Volume 29 - 2023 YEAR=2023 URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2023.1611033 DOI=10.3389/pore.2023.1611033 ISSN=1532-2807 ABSTRACT=

Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and pemetrexed, as well as targeted agents. However, the emergence of drug resistance evidence in poor patient outcomes and poor prognosis is a motivation to determine the specific mechanism of drug resistance. Interestingly, circular RNAs (circRNAs) play an important part in the carcinogenesis and progression of GC and are involved in GC drug resistance. This review systematically summarizes the functions and mechanisms of circRNAs underlying GC drug resistance, especially chemoresistance. It also emphasizes that circRNAs can serve as promising targets for improving drug resistance and therapeutic efficacy.