AUTHOR=Zheng Ying , Li Zhe , Wang Yao , Chen Wanjiao , Lin Yifan , Guo Junming , Ye Guoliang 

TITLE=CircRNA: A new class of targets for gastric cancer drug resistance therapy

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 29 - 2023

YEAR=2023

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2023.1611033

DOI=10.3389/pore.2023.1611033

ISSN=1532-2807

ABSTRACT=Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced gastric cancer need palliative care to ensure survival, such as chemotherapy agents including cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel and pemetrexed, as well as targeted agents and so on. Nonetheless, the emergence of drug resistance results in poor patient outcomes and poor prognosis which motivates us to find the specific mechanism of drug resistance. Interestingly, circular RNAs (circRNAs) have been found play an important part in the carcinogenesis and progression of GC, which are involved in the drug resistance of GC at the same time. In this review, we systematically summarized the functions and mechanisms of circRNAs underlying drug resistance of GC, especially chemoresistance. We further emphasize that circRNAs can serve as promising targets for improving drug resistance and therapeutic efficacy.