AUTHOR=Janka Mária , Zalatnai Attila 

TITLE=Correlations between the histopathological alterations in minor salivary glands and the clinically suspected Sjögren’s syndrome

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 29 - 2023

YEAR=2023

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2023.1610905

DOI=10.3389/pore.2023.1610905

ISSN=1532-2807

ABSTRACT=In sicca syndrome patients the xerostomia, xerophthalmia and the serological findings may strongly suggest the autoimmune Sjögren syndrome, but the histological findings in the labial salivary gland biopsies not always justify the suspected diagnosis. The aim of this study was to compare the histomorphological changes and the clinical findings in patients with pathologically established Sjögren syndrome and in cases with negative histology. One hundred and thirty-three labial biopsies have been retrospectively evaluated from 2015 to May 2022, and the characteristic Sjögren lesions were found in 67 cases. According to the clinical data 34 cases proved to be primary, and 33 secondary forms. In 66 cases the histology did no justify the Sjögren syndrome; a significant acinar loss, fibrolipomatous infiltration and mild sialadenitis have led to the clinical symptoms. In Sjögren-histologies acinar loss was detected just in 31,8%, which might indicate that the diminished saliva production represents immune-mediated hypofunction rather than direct damage of the acini.