AUTHOR=AlQudah Mohammad , Khalifeh Mohammad , Al-Azaizeh Rasha , Masaadeh Amr , Al-Rusan Omar M. , Haddad Husam K. 

TITLE=Hyperbaric oxygen exposure alleviate metabolic side-effects of olanzapine treatment and is associated with Langerhans islet proliferation in rats

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 28 - 2022

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610752

DOI=10.3389/pore.2022.1610752

ISSN=1532-2807

ABSTRACT=Olanzapine (OLZ) is one of the second-generation antipsychotics drugs (APDs) used to treat several psychiatric illnesses. OLZ treatment is often associated with many metabolic side effects in a dose dependent manner such as obesity, dyslipidemia and insulin resistance, induction of type II diabetes and acute pancreatitis in some patients. In the current study, Hyperbaric Oxygen therapy (HBOT) was investigated as a tool to mitigate OLZ metabolic side effects in rats. Thirty-six female Sprague Dawley (SD) rats were divided into 4 groups; rats on OLZ treatment either exposed to HBOT (HBOOLZ) or left without exposure (OLZ) then non-treated rats that either exposed to HBOT or left without exposure (control). Rats received HBOT for 35 days at 2.4 atmospheres absolute (ATA) for 2.5 hours daily followed by intraperitoneal injection of OLZ at 10 mg/kg or placebo. Rats on either HBOT or OLZ had a significant loss in body weight. OLZ treatment showed a decrease in serum insulin level, triglyceride, high-density lipoprotein (HDL) cholesterol, and lipase level but an increase in fasting blood sugar (FBS), insulin resistance index (HOMA-IR) and amylase, while rats’ exposure to HBOT reversed these effects. The Pancreatic Langerhans islets were up-regulated in both HBOT and OLZ treatments but the combination (HBOOLZ) doubled these islets number. This study advocated that HBOT can be an alternative approach to control or reverse many metabolic disorders (MDs) associated with OLZ treatment. In addition, it seems that HBOT positively affect the pancreatic Langerhans cells activity and architecture.