AUTHOR=Tímár József , Uhlyarik Andrea 

TITLE=On-Target Side Effects of Targeted Therapeutics of Cancer

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 28 - 2022

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610694

DOI=10.3389/pore.2022.1610694

ISSN=1532-2807

ABSTRACT=The concept of precision medicine is based on the identification of hallmarks of cancer to exploit them as drug targets. The basic idea was that in this way therapeutic modalities were going to  be more effective and side effects  fewer. Since the majority of these novel modalities are not specific for a cancer-related biological process or a cancer-specific (mutant) target protein, it is no surprise that we had to learn new types of side effects, since these therapeutics also affect physiological or pathological processes. Even more, in the case of some of these novel therapies we were able to discover new molecular mechanisms of physiological and pathological processes. Identification of on-target side effects of targeted drugs can help  prevent their development  or better manage them when they emerge during cancer therapy.