AUTHOR=Zijtregtop Eline A. M. , Tromp Ilse , Dandis Rana , Zwaan Christian M. , Lam King H. , Meyer-Wentrup Friederike A. G. , Beishuizen Auke 

TITLE=The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 28 - 2022

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610482

DOI=10.3389/pore.2022.1610482

ISSN=1532-2807

ABSTRACT=Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC is associated with treatment success or failure and the interim remission status. Only low expression of PD-L1 was significantly associated with complete remission at interim PET-scan, which should be further investigated. There was no association between marker expression and treatment success. Our data suggest a difference between pediatric and adult cHL. This underlies the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.