AUTHOR=Mátrai Zoltán , Kelemen Péter , Kósa Csaba , Maráz Róbert , Paszt Attila , Pavlovics Gábor , Sávolt Ákos , Simonka Zsolt , Tóth Dezső , Kásler Miklós , Kaprin Andrey , Krivorotko Petr , Vicko Ferenc , Pluta Piotr , Kolacinska-Wow Agnieszka , Murawa Dawid , Jankau Jerzy , Ciesla Slawomir , Dyttert Daniel , Sabol Martin , Zhygulin Andrii , Avetisyan Artur , Bessonov Alexander , Lázár György TITLE=Modern Breast Cancer Surgery 1st Central-Eastern European Professional Consensus Statement on Breast Cancer JOURNAL=Pathology and Oncology Research VOLUME=Volume 28 - 2022 YEAR=2022 URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610377 DOI=10.3389/pore.2022.1610377 ISSN=1532-2807 ABSTRACT= As part of the up-to-date multidisciplinary treatment of breast cancer, organ specialized onco-surgery, breast surgery has evolved in many ways over the past decades. The most important causes of this progession are the evidence based clinical science, the biological concept of cancer treatment, the tendency of early diagnosis thanks to populational breast screening programmes and the wide spread of breast cancer awareness, the technological advances in diagnosis, pathology, molecular genetics, pharmacology, radiotherapy and surgery, the quality assured centralization of breast cancer care, and the increased importance of rehabilitation and quality of life. In breast cancer surgery, the principle of minimally effective treatment instead of maximally tolerable treatment has become basic principle and practice. Up to date surgical therapy for breast cancer will be determined by increasingly precise diagnostic and tumor localizing methods as well as increasingly effective oncology treatment procedures. Organ preserving surgery in combination with primary systemic treatments and the application of oncoplastic principles have become widespread. Sentinel lymph node biopsy is a primary approach in the surgical treatment of the clinically negative axilla, and the indication for axillary lymph node dissection has further decreased by the contribution of regional radiotherapy, medical treatment and targeted axillary surgery. Hereunder we summarise our recommendations on the surgical treatment of breast cancer based on the content of the 4th Hungarian Breast Cancer Consensus Conference as the 1st Central Eastern European Consesnsus Statement on Breast Cancer Surgery (1) and considering the latest international studies and professional recommendations (2–9).