AUTHOR=Xia Hailong , Deng Lei , Meng Shu , Liu Xipeng , Zheng Chao 

TITLE=Single-Cell Transcriptome Profiling Signatures and Alterations of Microglia Associated With Glioblastoma Associate Microglia Contribution to Tumor Formation

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 28 - 2022

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610067

DOI=10.3389/pore.2022.1610067

ISSN=1532-2807

ABSTRACT=The most conventional tumor of the central nervous system in children and adults is glioblastoma (GBM). Clinically, they are classified as low-grade to high-grade (I to IV) GBMs, which have limited effective therapy methods and poor curative effect for malignant GBM accompanied by the deepening of research and the development of technology, a large number of monocytes, mainly macrophages and microglia cells (MG), have been found in the tumor tissue of GBM. Both those two monocytes play an important role in the genesis and development of GBM. Macrophages are recruited during tumorigenesis, while MG are present in the brain during embryonic development. Interestingly, the accumulation of these monocytes was inversely associated with adult GBM survival, but not with childhood GBM. In this paper, the heterogeneity of MG in tumor lesions was analyzed by single-cell RNA-seq data, so as to explore the roles of different MG subtype during the genesis and progression of GBM.