AUTHOR=Yao Jin-Ming , Zhao Jun-Yu , Lv Fang-Fang , Yang Xue-Bo , Wang Huan-Jun 

TITLE=A Potential Nine-lncRNAs Signature Identification and Nomogram Diagnostic Model Establishment for Papillary Thyroid Cancer

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 28 - 2022

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610012

DOI=10.3389/pore.2022.1610012

ISSN=1532-2807

ABSTRACT=The purpose of our current study was to establish an lncRNAs signature and assess its prognostic power in PTC. LncRNAs expression profiles were obtained from the Cancer Genome Atlas (TCGA). The key module and hub lncRNAs related to PTC were determined by weighted gene co-expression network analysis (WGCNA) and LASSO Cox regression analyses, respectively. Functional enrichment analyses, including GO, KEGG and GSEA, were implemented to analyze the possible biological processes and signaling pathways of hub lncRNAs. Association between key lncRNAs expression and tumor-infiltrating immune cells was identified using TIMER website. KM Plotter was used to validate the prognostic significance of hub genes in PTC. A diagnostic model was conducted with logit regression analysis, and its diagnostic performance was assessed by calibration/ receiver operating characteristic (ROC) curves and principal component analysis (PCA). A nine-lncRNAs signature (SLC12A5-AS1, LINC02028, KIZ-AS1, LINC02019, LINC01877, LINC01444, LINC01176, LINC01290 and LINC00581) was established in PTC, which has significant diagnostic and prognostic powers. Functional enrichment analyses elucidated that the nine-lncRNAs signature may be involved in the development of PTC. The expression of nine hub lncRNAs was correlated with the levels of tumor infiltrating immune cells. A diagnostic nomogram was also established for PTC. In conclusion, our present research established an innovative nine-lncRNAs signature and a six-lncRNAs nomogram that might act as a potential indicator for PTC prognosis and diagnosis, which could be conductive to the PTC treatment.