AUTHOR=Bai Rui , Diao Bowen , Li Kaili , Xu Xiaohan , Yang Ping 

TITLE=Serum Tie-1 is a Valuable Marker for Predicting the Progression and Prognosis of Cervical Cancer

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 27 - 2021

YEAR=2021

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2021.1610006

DOI=10.3389/pore.2021.1610006

ISSN=1532-2807

ABSTRACT=Abstract
Objective: To investigate whether sTie-1 is a valuable marker for predicting the progression and prognosis of cervical cancer.
Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect serum Tie-1 (sTie-1) concentrations in patients of 75 cervical cancer, 54 squamous intraepithelial lesions (SIL) and 55 healthy controls without cervical lesions, and sTie-1 levels were compared between the three groups. The receiver operating characteristic curves (ROC) was used to evaluate the diagnostic values of sTie-1. The relationship between sTie-1 concentration in patients with cervical cancer and their clinicopathological features and prognosis was analyzed. Cox univariate and multivariate proportional analysis were performed to predict the risk factors of postoperative recurrence in 68 followed-up cervical cancer patients. 
Results: From healthy women to patients of SIL, then to cervical squamous cell carcinoma, the concentration of sTie-1 gradually increased (P＜0.05), and sTie-1 was also elevated significantly in adenocarcinoma（P＜0.05) compared with healthy controls. The area under ROC curves of sTie-1 to discriminate cervical cancer patients from normal was 0.846(P=0.001). Increased sTie-1 in 75 cervical cancer patients had significant association with tumor size, advanced tumor stage (FIGO 2018), lymph node metastasis (LNM) and poorer progression free survival (PFS) (P＜0.05). Cox multivariate analysis model showed that cervical cancer patients with high sTie-1 concentration had 4.359 times (95% CI：1.386-13.715, P = 0.007) higher risk for tumor recurrence than those with Low sTie-1. 
Conclusions: Elevated sTie-1 in patients of cervical carcinoma has an association with tumor progression and poor prognosis. In the future, sTie-1 is a valuable marker for predicting the progression and prognosis of cervical cancer.