AUTHOR=Youssef Heba M. K. , Radi Dina A. , Abd El-Azeem Marwa A. 

TITLE=Expression of TSP50, SERCA2 and IL-8 in Colorectal Adenoma and Carcinoma: Correlation to Clinicopathological Factors

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 27 - 2021

YEAR=2021

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2021.1609990

DOI=10.3389/pore.2021.1609990

ISSN=1532-2807

ABSTRACT=Background: Colorectal cancer (CRC) is the third most common type of cancers, it is  considered as a genetically heterogeneous disease with different molecular pathways are involved in its initiation and progression. Testes-specific protease 50 (TSP50) gene is a member of cancer/testis antigens encodes a threonine protease enzyme, overexpression of TSP50 was found to enhance the progression and invasion of breast cancer and other malignant tumours. SERCA2 is widely expressed in several body tissues, its aberrant expression has been involved in many cancers. IL-8 is an inflammatory cytokine, beside its role in inflammation, its expression was reported to induce the migration of tumour cells.
Aim: Study the expression of TSP50, SERCA2 and IL-8 in colorectal adenoma (CRA), CRC and normal colonic tissues to compare the expression of these biomarkers in relation to clinicopathological parameters and prognostic factors.
Results: TSP50, SERCA2 and IL-8 expression varied between normal colonic tissues, CRA and CRC. Significant statistical association was detected between the three biomarkers’ overexpression and degree of dysplasia in CRA. Also, Significant statistical relation was found between the three biomarkers’ overexpression and presence of lympho-vascular invasion, advanced TNM staging and high intra-tumoural inflammatory infiltrate with significant positive correlation between them.    
Conclusion: TSP50, SERCA2 and IL-8 expression was different between normal tissue and neoplastic colorectal tissue on one hand and between CRA and CRC on the other hand. Increased expression of these biomarkers in neoplastic epithelial cells of colorectal carcinoma is associated with adverse prognostic factors and could be considered as independent prognostic factors.