AUTHOR=Yu KeXuan , Wang Yiqin 

TITLE=The Advance and Correlation of KRAS Mutation With the Fertility-Preservation Treatment of Endometrial Cancer in the Background of Molecular Classification Application

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 27 - 2021

YEAR=2021

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2021.1609906

DOI=10.3389/pore.2021.1609906

ISSN=1532-2807

ABSTRACT=The annually increasing incidence of endometrial cancer in younger women has aroused a growing demand for fertility preservation. However, the diverse therapeutic efficacy among the patients under the same histological subtype and the same tumor grade suggests the potential interference of the innate molecular characteristics. The molecular classification now has been applied in the clinical practice and might help to stratify the EC patients and individualize the therapy, but the candidates for the fertility-spared treatment are most likely to be subdivided in the group lacking the specific signature. KRAS mutation has been linked to the malignant transition of the endometrium, while its role in molecular classification and fertility preservation is vague. Here, we mainly review the advance of molecular classification and the role of KRAS in endometrial cancer, as well as their correlation with fertility-preservation treatment.