AUTHOR=Mikhaleva Ludmila M., Chernayev Andrey L., Samsonova Maria V., Zayratyants Oleg V., Kakturskiy Lev V., Vasyukova Olesya A., Birukov Andrey E., Kontorshchikov Andrey S., Sorokina Anastasia V., Sinelnikov Mikhail Y.

TITLE=Pathological Features in 100 Deceased Patients With COVID-19 in Correlation With Clinical and Laboratory Data

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 27 - 2021

YEAR=2021

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2021.1609900

DOI=10.3389/pore.2021.1609900

ISSN=1532-2807

ABSTRACT=Background. Autopsies on COVID-19 deceased patients has many limitations due to necessary epidemiologic and preventative measures. The ongoing pandemic has caused significant strain on healthcare systems and is being extensively studies around the world. Clinical data does not always corelate with post-mortem findings. The goal of our study was to find pathognomonic factors associated with COVID-19 mortality in 100 post-mortem full autopsies.  Materials and methods. Under necessary precautions, we performed 100 autopsies on patients who were diagnosed with COVID-19 related death. The macroscopic and microscopic pathologies were evaluated. The entire body was analyzed and all findings were documented. Results. Extensive coagulopathic changes were seen throughout the bodies of diseased patients. Diffuse alveolar damage was pathognomonic of COVID-19 viral pneumonia. Extrapulmonary pathology was predominantly seen in the liver and spleen. Intravascular thrombosis was widespread and signs of septic shock were often present. Conclusion. The described pathological manifestation of COVID-19 in deceased patients are an insight into the main mechanisms of SARS-CoV-2 associated lethal outcome.